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Figure 5 | Journal of Neuroinflammation

Figure 5

From: CaMKII and MEK1/2 inhibition time-dependently modify inflammatory signaling in rat cerebral arteries during organ culture

Figure 5

Effect of the MEK1/2 inhibitor on p-p38 and p-JNK levels in incubated arteries (A) Fluorescence intensity and (B) expression of p-p38 and p-JNK in the vascular smooth muscle cell layer of cerebral arteries incubated for 24 hours in presence or absence of the MEK1/2 inhibitor U0126 added at 0 or 6 hours after initiating incubation. (A, D) Arteries incubated for 24 hours in presence of vehicle were used as control. (B, E) U0126 added at 0 hours, (C, F) U0126 added at 6 hours. Data are presented as mean ± SEM relative to control. n = 5 *P <0.05, **P <0.01, ***P <0.001. Calcium calmodulin-dependent protein kinase II (CAMKII), phosphorylated c-Jun N-terminal kinase (p-JNK).

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