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Figure 5 | Journal of Neuroinflammation

Figure 5

From: Role of anti-inflammatory compounds in human immunodeficiency virus-1 glycoprotein120-mediated brain inflammation

Figure 5

Effect of gp120 on the mRNA levels of (A) IL-1β, (B) iNOS and (C) TNF-α in different brain regions of ICV-administered gp120 rats receiving simultaneous intraperitoneal injection of chloroquine or minocycline or simvastatin. Saline-injected animals were used as control. Results are expressed as mean ± SEM. Samples obtained from at least 10 different animals were used per group. Asterisks represent data points significantly different from saline-administered animals (***P <0.001; **P <0.01; *P <0.05). Diamonds represent data points significantly different from gp120 treatment (♦♦♦P <0.001; ♦♦P <0.01). (gp120 = glycoprotein120; IL-1β = interleukin-1β; iNOS = inducible nitric oxide synthase; TNFα = tumor necrosis factor-α; ICV = intracerebroventricular; CQ = chloroquine; Mino = minocycline; Sim = simvastatin).

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