Figure 6

ELISA analysis of (A) IL-1β and (B) TNF-α secretion in the CSF of gp120 (500 ng) administered rats receiving simultaneous intraperitoneal injection of chloroquine or minocycline or simvastatin. CSF collected from saline-injected animals was used as a control. Results are expressed as mean ± SEM. Samples obtained from at least 10 different animals were used per group. Asterisks represent data points significantly different from saline-administered animals (***P <0.001; **P <0.01). Diamonds represent data points significantly different from gp120 treatment (♦♦♦P <0.001). (ELISA = Enzyme linked immunoabsorbant assay; IL-1β = interleukin 1β; TNFα = tumor necrosis factorα; CSF = cerebrospinal fluid; gp120 = glycoprotein120; CQ = chloroquine; Mino = minocycline; Sim = simvastatin).