Figure 7

Protein (upper panel) and densitometric analysis (lower panel) of (A) ERK1/2 and phospho-ERK1/2; JNK and phospho-JNK; P38K and phospho-P38K, (B) ERK1/2 and phospho-ERK1/2 in the presence of chloroquine, minocycline and simvastatin, (C) ERK1/2 and phospho-ERK1/2 in the presence of ERK1/2 inhibitor U0126; (D) JNK and phospho-JNK in the presence of SP600125 in the hippocampal tissue of gp120-administered rats. Representative blots are shown. Tissue collected from saline-administered animals was used as control. Results are expressed as mean ± SEM. Samples obtained from three to six different animals per group were used. Asterisks represent data points significantly different from saline-administered animals (***P <0.001; *P <0.05). Diamonds represent data points significantly different from gp120-treatment (♦P <0.05). (ERK1/2 = extracellular signal-related kinase 1/2; p-ERK1/2 = phospho- ERK1/2; JNKs = c-Jun N-terminal kinases; p-JNKs = phospho-JNKs; P38Ks = P38 kinases; p-P38Ks = phosphor-p38Ks; gp120 = glycoprotein120).