Skip to main content
Figure 2 | Journal of Neuroinflammation

Figure 2

From: Impact of the neutrophil response to granulocyte colony-stimulating factor on the risk of hemorrhage when used in combination with tissue plasminogen activator during the acute phase of experimental stroke

Figure 2

Effect of subcutaneous administration of G-CSF (60 μg/kg; 30 μL) or vehicle on the endothelium-dependant function of the middle cerebral artery. (a) Dose-response to acetylcholine after ischemia/reperfusion and thrombolysis. Endothelial relaxation was expressed as percentage of change in diameter of pre-constricted arteries measured after 72 hours of reperfusion. (b) Dose response to acetylcholine after vinblastine pretreatment in control rats. Vinblastine was used for neutrophil depletory and administered four days before the administration of G-CSF. Values are mean ± SEM. *P <0.05 versus control; § P <0.05 versus control G-CSF; #P <0.001 versus control. Ach, acetylcholine; G-CSF, granulocyte colony stimulating factor.

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094