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Table 1 Neutrophil counts on peripheral blood before surgery and after 24 h and 72 h of reperfusion in rats submitted to ischemia/reperfusion and tPA and treated by vehicle (saline 0.9%) or granulocyte colony stimulating factor (G-CSF 60 μg/kg; 30 μL)

From: Impact of the neutrophil response to granulocyte colony-stimulating factor on the risk of hemorrhage when used in combination with tissue plasminogen activator during the acute phase of experimental stroke

Neutrophils (/mm3)

Vehicle (n = 9)

G-CSF (n = 10)

Before ischemia

1808 ± 665

1645 ± 229

24 hours after ischemia

2993 ± 350*

6626 ± 1570*#

72 hours after ischemia

865 ± 444

1176 ± 587

  1. Mean ± SEM. *p < 0.05 vs basal state; #p < 0.0001 vs vehicle. G-CSF, Granulocyte colony stimulating factor; tPA, tissue plasminogen activator, SEM standard error of the mean.