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Table 2 Histologic examination of incidence and severity of intracerebral hemorrhages after 72 h of reperfusion in rats submitted to ischemia/reperfusion and tPA and treated by vehicle (saline 0.9%) or granulocyte colony stimulating factor (G-CSF 60 μg/kg; 30 μL)

From: Impact of the neutrophil response to granulocyte colony-stimulating factor on the risk of hemorrhage when used in combination with tissue plasminogen activator during the acute phase of experimental stroke

 

Histologic score

Severity

0 = no hemorrhage (n)

1 = macroscopically visible hemorrhages (n)

2 = hematoma (n)

Mean number of petechial hemorrhages ± SEM

Vehicle (n = 9)

1

8

0

4.1 ± 0.9

G-CSF (n = 10)

0

10

4*

10.3 ± 1.8 *

  1. *p < 0.05 vs vehicle. G-CSF, Granulocyte colony stimulating factor; tPA, tissue plasminogen activator, SEM standard error of the mean.
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Journal of Neuroinflammation

ISSN: 1742-2094