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Table 1 M2 markers

From: Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

M2 marker Function Expressed in murine microglia? Expressed in human microglia? Reference
Arginase 1 (Arg1) Converts L-arginine into prolines and polyamines implicated in tissue remodeling and wounding healing. It competes with iNOS for substrates. Yes Debated: evidence suggests it is not upregulated in human beings but others have shown elevations in the CNS. [6, 27, 28, 32, 33]
Ym1 (Chi3l3) A secretory lectin that binds heparin/heparan sulfate. It is proposed to prevent degradation of extra cellular matrix components. Yes Similar to arginase 1 as it has been seen in human beings. However, it might not be expressed in M2 microglia. [6, 3033]
FIZZ1 (RetnlB) Mediates interactions between sensory nerves and inflammatory cells in the lungs. It blocks nerve growth factor induced survival of dorsal root ganglion neurons. Yes Unknown [31, 34, 35]
MRC (CD206) Binds and internalizes/phagocytoses mannosylated ligands. No, limited to perivascular macrophages and meninges Observed in vitro. [3638]
CD163 Binds and internalizes hemoglobin-haptoglobin complex. Yes Yes [3941]
TREM2 The endogenous ligand is unknown, but thought be involved in debris clearance. Yes Yes [42, 43]
Dectin-1 (Clec7A) Recognizes β-glucans and can lead to phagocytosis. Yes Observed in human macrophages but unknown whether it is expressed in human microglia. [19, 44, 45]
CD301 (MGL1) Recognizes terminal galactose and N-acetylgalactosamine. Involved in pathogen defense and related to CD206. Yes (our observations) Unknown [46]