A: Two twi/twi at PND 44, one ibudilast-treated and other vehicle-treated from PND 30. The ibudilast-treated twi/twi is much bigger and can walk faster and reach the feedbox, in spite of mild paralysis and spasticity in lower limbs. In contrast, the vehicle-treated twi/twi can no longer walk nor feed itself. In addition, the ibudilast-treated twi/twi has much milder tremor than the vehicle-treated twi/twi. B: The change of body weight (g) of ibudilast- and vehicle-treated twi/twi. Both twi/twi treated with ibudilast or vehicle from PND 15 (●: ibudilast-treated twi/twi, ○: vehicle-treated twi/twi) showed less weight gain compared with those treated from PND 30 (■: ibudilast-treated twi/twi, □: vehicle-treated twi/twi), and no prolongation of the life span. However, ibudilast-treated twi/twi showed less body weight loss than vehicle-treated twi/twi. N = 3 and 2 in ibudilast- and vehicle-treated twi/twi from PND 15. The ibudilast-treated twi/twi from PND 30 were bigger and showed milder clinical detrerioration. N = 5 and 4 in ibudilast- and vehicle-treated twi/twi from PND 30. The data represent mean ± SE.