Ibudilast-treated twi/twi show pathological improvement. Population of TUNEL-positive cells and neuropathological scores of LFB-PAS in ibudilast- (closed-boxed; N = 4) or vehicle-treated (hatched; N = 3) twi/twi. In CWM, 8 n, and sp5 of the ibudilast-treated twi/twi, the number of TUNEL-positive cells is decreased to half of those in the vehicle-treated twi/twi. They also recognized significantly milder demyelination in LFB-PAS stain. 8 n: the 8th nerve. *p < 0.01, **p < 0.05. The error bars represented standard deviations.