Sublesional distribution of CX
CR1 expressing cells. Cellular infiltrations in the MOG-EAE rat brain (early relapse phase; day 21 post immunization) are observed with hematoxylin-eosin staining (upper left). Areas of active demyelination are revealed with Luxol fast blue/PAS staining (upper right). Actively phagocytozing cells are detected with immunohistochemical staining for ED-1 (lower left). This figure exemplifies the uneven distribution of CX3CR1 mRNA expressing cells (lower right) within the inflammatory aggregates.