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Table 3 Inflammation-related transcript levels remain stable in the hippocampus of 2, 3, and 6 month-old 3xTg-AD and control mice. Total RNA was purified from microdissected hippocampus from 2, 3, and 6 month-old 3xTg-AD and non-transgenic control mice. cDNA was generated and subjected to Applied Biosystems Microfluidic Card analysis of 23 inflammation-related transcriptional targets. None of the transcriptional targets assessed exhibited altered expression at any of the assessed time-points. Proinflammatory transcript expression in 3xTg-AD and non-transgenic mice in the hippocampus

From: Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice

  3xTg-AD Non-Transgenic
  3 months 6 months 3 months 6 months
Marker Fold Change (Relative to 2 months) Fold Change (Relative to 2 months) Fold Change (Relative to 2 months) Fold Change (Relative to 2 months)
C3 1.181 +/- 0.855 1.006 +/- 0.473 0.754 +/- 0.385 1.123 +/- 0.734
MCP-1 (CCL2) 0.554 +/- 0.72 0.204 +/- 0.122 1.864 +/- 0.756 1.392 +/- 0.709
CCL3 0.621 +/- 0.353 0.571 +/- 0.339 0.664 +/- 0.305 0.638 +/- 0.369
Fractalkine 0.619 +/- 0.136 0.718 +/- 0.256 0.973 +/- 0.086 0.919 +/- 0.240
IP10 0.347 +/- 0.154 0.388 +/- 0.246 1.185 +/- 0.552 0.796 +/- 0.481
TNF-α 0.238 +/- 0.278 0.216 +/- 0.195 0.899 +/- 0.432 0.461 +/- 0.348
TGF-β 0.683 +/- 0.187 0.793 +/- 0.138 1.117 +/- 0.178 0.935 +/- 0.468
IL-2 0.650 +/- 0.077 0.637 +/- 0.055 0.360 +/- 0.228 0.462 +/- 0.447
IL-6 0.373 +/- 0.215 0.531 +/- 0.524 0.719 +/- 0.320 0.396 +/- 0.506
IL-8 0.180 +/- 0.228 0.198 +/- 0.170 0.292 +/- 0.202 0.206 +/- 0.105
IL-1α 0.602 +/- 0.111 0.838 +/- 0.229 0.766 +/- 0.431 0.825 +/- 0.552
IL-1β 0.449 +/- 0.687 0.517 +/- 0.885 1.489 +/- 1.711 1.672 +/- 1.570
IL-12α 1.597 +/- 2.736 3.329 +/- 7.112 0.362 +/- 0.364 0.678 +/- 0.747
ICAM 1 0.771 +/- 0.174 0.756 +/- 0.162 1.075 +/- 0.163 0.941 +/- 0.324
VCAM 1 0.730 +/- 0.175 0.738 +/- 0.173 0.943 +/- 0.191 0.833 +/- 0.337
CD4 0.603 +/- 0.751 0.681 +/- 0.822 1.258 +/- 0.750 1.190 +/- 0.847
CD8 0.534 +/- 0.484 0.943 +/- 1.047 1.127 +/- 1.011 10.462 +/- 10.77
CD80 0.464 +/- 0.353 0.349 +/- 0.249 1.116 +/- 0.496 1.117 +/- 1.079
CD86 0.614 +/- 0.126 0.614 +/- 0.163 0.893 +/- 0.112 0.686 +/- 0.307
Ptgs1 0.771 +/- 0.153 0.913 +/- 0.262 1.013 +/- 0.105 1.025 +/- 0.287
Ptgs2 0.649 +/- 0.309 0.936 +/- 0.351 1.060 +/- 0.092 0.868 +/- 0.370
Caspase 3 0.556 +/- 0.145 0.569 +/- 0.119 0.830 +/- 0.187 0.697 +/- 0.243
VEGF 0.728 +/- 0.196 0.723 +/- 0.169 0.819 +/- 0.111 0.809 +/- 0.257