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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Effects of the cyclooxygenase-2 inhibitor nimesulide on cerebral infarction and neurological deficits induced by permanent middle cerebral artery occlusion in the rat

Figure 1

Temporal development of focal cerebral infarction induced by permanent middle cerebral artery occlusion (pMCAO). (A): Evolution of cortical and subcortical infarct volumes after pMCAO in rats. Representative TTC-stained sections at different times after stroke are shown in the insets. (B) and (C): Time course of the increase of neurological deficits and motor impairment induced by pMCAO. Infarct volumes are expressed as a percentage of the contralateral (control) hemisphere. Bars represent the group mean ± SD. * p < 0.05 with respect to subcortical infarct volume at 4 h. &p < 0.05 with respect to subcortical infarct volume at 8 h. # p < 0.05 with respect to cortical infarct volume at 8 h. ** p < 0.05 with respect to cortical infarct volume at 12 h. § p < 0.05 with respect to 4 and 8 h. The horizontal bar in Panel B shows the median neurological score.

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