Figure 1From: Effects of the cyclooxygenase-2 inhibitor nimesulide on cerebral infarction and neurological deficits induced by permanent middle cerebral artery occlusion in the ratTemporal development of focal cerebral infarction induced by permanent middle cerebral artery occlusion (pMCAO). (A): Evolution of cortical and subcortical infarct volumes after pMCAO in rats. Representative TTC-stained sections at different times after stroke are shown in the insets. (B) and (C): Time course of the increase of neurological deficits and motor impairment induced by pMCAO. Infarct volumes are expressed as a percentage of the contralateral (control) hemisphere. Bars represent the group mean ± SD. * p < 0.05 with respect to subcortical infarct volume at 4 h. &p < 0.05 with respect to subcortical infarct volume at 8 h. # p < 0.05 with respect to cortical infarct volume at 8 h. ** p < 0.05 with respect to cortical infarct volume at 12 h. § p < 0.05 with respect to 4 and 8 h. The horizontal bar in Panel B shows the median neurological score.Back to article page