Figure 2From: Effects of the cyclooxygenase-2 inhibitor nimesulide on cerebral infarction and neurological deficits induced by permanent middle cerebral artery occlusion in the ratReduction of subcortical (A), cortical (B) and total (C) infarct volumes by the cyclooxygenase-2 inhibitor nimesulide (12 mg/kg; i.p.) when its first administration was delayed for several hours after the onset of permanent stroke. Nimesulide reduced the infarct size in animals treated at 0.5 (n = 8), 1 (n = 9) and 2 h (n = 9), but not at 3 (n = 11) and 4 h (n = 9) after pMCAO, compared to vehicle-treated and time-comparable control groups (n = 7–9 per group). Infarct volumes are expressed as a percentage of the contralateral (control) hemisphere and the data are represented as the mean ± SD. * p < 0.05 and ** p < 0.01 with respect to vehicle (Student's t-test).Back to article page