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Table 3 Effect of delayed administration of nimesulide (12 mg/kg; i.p.) on neurological deficit score and rotarod performance after permanent middle cerebral artery occlusion (pMCAO) in rats. Vehicle or nimesulide was administered 0.5, 1, 2, 3, or 4 h after stroke.

From: Effects of the cyclooxygenase-2 inhibitor nimesulide on cerebral infarction and neurological deficits induced by permanent middle cerebral artery occlusion in the rat

 

Neurological Score

Rotarod performance (%)

Time after stroke (h)

Vehicle

Nimesulide

Vehicle

Nimesulide

0.5

3 (2–5)

2 (1–3) **

44 ± 17

81 ± 18 **

1

3 (2–5)

2 (1–4) **

40 ± 21

85 ± 22 **

2

3 (3–5)

2 (1–5) *

50 ± 11

73 ± 13 *

3

3 (2–5)

3 (2–5)

47 ± 16

60 ± 15

4

3.5 (2–5)

3 (2–5)

52 ± 23

59 ± 14

  1. Values represent the median and range (neurological score) and means ± S.D. (rotarod performance). *P < 0.05 and **P < 0.01 compared with the corresponding vehicle-treated group.