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Table 3 Effect of delayed administration of nimesulide (12 mg/kg; i.p.) on neurological deficit score and rotarod performance after permanent middle cerebral artery occlusion (pMCAO) in rats. Vehicle or nimesulide was administered 0.5, 1, 2, 3, or 4 h after stroke.

From: Effects of the cyclooxygenase-2 inhibitor nimesulide on cerebral infarction and neurological deficits induced by permanent middle cerebral artery occlusion in the rat

  Neurological Score Rotarod performance (%)
Time after stroke (h) Vehicle Nimesulide Vehicle Nimesulide
0.5 3 (2–5) 2 (1–3) ** 44 ± 17 81 ± 18 **
1 3 (2–5) 2 (1–4) ** 40 ± 21 85 ± 22 **
2 3 (3–5) 2 (1–5) * 50 ± 11 73 ± 13 *
3 3 (2–5) 3 (2–5) 47 ± 16 60 ± 15
4 3.5 (2–5) 3 (2–5) 52 ± 23 59 ± 14
  1. Values represent the median and range (neurological score) and means ± S.D. (rotarod performance). *P < 0.05 and **P < 0.01 compared with the corresponding vehicle-treated group.