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Figure 3 | Journal of Neuroinflammation

Figure 3

From: Intracranial administration of deglycosylated C-terminal-specific anti-Aβ antibody efficiently clears amyloid plaques without activating microglia in amyloid-depositing transgenic mice

Figure 3

Thioflavine S labeled compact amyloid deposits are reduced following intracranial administration of anti-Aβ antibody. Panels B, D, and F show total thioflavine S staining of compact amyloid deposits in left (untreated) hippocampal regions of 20 mo. old APP transgenic mice. Panels A, C, and E show total thioflavine S staining in right hippocampal regions of 20 mo. old APP transgenic mice receiving intracranial injection of control antibody (panel A) or anti-Aβ C-terminal antibody (2H6; panel C), or deglycosylated anti-Aβ C-terminal antibody (de-2H6; panel E). Magnification = 40×, scale bar = 50 μm. Panel G shows quantification of the amyloid load as the ratio of injected (right) side to uninjected (left) side for both the hippocampal and frontal cortical injection sites * indicates P < 0.05 compared to mice injected with control IgG.

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Journal of Neuroinflammation

ISSN: 1742-2094