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Figure 4 | Journal of Neuroinflammation

Figure 4

From: Intracranial administration of deglycosylated C-terminal-specific anti-Aβ antibody efficiently clears amyloid plaques without activating microglia in amyloid-depositing transgenic mice

Figure 4

Fcγ receptor expression is increased following intracranial administration of intact anti-Aβ antibody but not deglycosylated anti-Aβ antibody. Panels A and B show Fcγ-receptor II/III staining in right hippocampal regions of 20 mo. old APP transgenic mice receiving intracranial injection of deglycosylated C-terminal anti-Aβ antibody (de-2H6) (panel A) or intact anti-Aβ C-terminal antibody (2H6; panel B). Magnification = 40×, scale bar = 50 μm. Panel C shows quantification of the Fcγ-R immunostaining as the ratio of injected (right) side to uninjected (left) side for both the hippocampal and frontal cortical injection sites. ** Indicates P < 0.01 versus both control IgG and de-2H6.

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Journal of Neuroinflammation

ISSN: 1742-2094