Inhibition of NF-κB activation by 5-lipoxygenase inhibitors protects brain against injury in a rat model of focal cerebral ischemia

Table 1 Physiologic parameters

	Vehicle		Caffeic acid		AA-861		BW-B 70C
	Basal	30 min Rep	Basal	30 min Rep	Basal	30 min Rep	Basal	30 min Rep
Rectal Temp (°C)	37.2 ± 0.3	36.8 ± 0.2	37.6 +0.2	36.5 ± 0.3	37.4 ± 0.4	37.3 ± 0.2	37.3 ± 0.3	37.4 ± 0.2
Cranial Temp (°C)	37.0 ± 0.5	37.3 ± 0.7	36.8 ± 0.2	36.9 ± 0.3	37.4 ± 0.3	36.9 ± 0.4	36.9 ± 0.2	37.1 ± 0.4
PCO2 (mm Hg)	56.9 ± 7.6	55.7 ± 8.0	51.4 ± 9.2	52.4 ± 6.9	55.9 ± 9.0	53.8 ± 9.7	58.5 ± 6.4	52.6 ± 7.8
PO2 (mm Hg)	41.5 ± 7.8	44.0 ± 5.2	48.5 ± 8.2	39.5 ± 8.9	43.5 ± 8.4	37.0 ± 5.6	45.5 ± 6.3	38.5 ± 6.5
MBP (mm Hg)	106 ± 14	101 ± 10	102 ± 23	112 ± 10	109 ± 13	107 ± 12	117 ± 19	121 ± 14
Glucose (mg/dL)	190.5 ± 15.2	214.8 ± 18.6	210.5 ± 12.5	191.6 ± 12.9	201.8 ± 11.9	181.6 ± 16.8	190.5 ± 17.5	202.6 ± 10.9
PH	7.3 ± 0.1	7.3 ± 0.2	7.3 ± 0.1	7.3 ± 0.1	7.2 ± 0.2	7.3 ± 0.1	7.3 ± 0.1	7.3 ± 0.2

Measurements were performed before MCAO (base) and at 30 min of reperfusion after drug administration as described in Methods. All measurements other than temperature were performed in blood. Data are presented as mean ± SD for n = 3 in each group. Measurements were also performed for sham group. No significant differences were observed among the groups. Basal, 30 min before MCAO; MBP, mean blood pressure; Rep, reperfusion; Temp, temperature

ISSN: 1742-2094