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Figure 6 | Journal of Neuroinflammation

Figure 6

From: Production of IL-16 correlates with CD4+ Th1 inflammation and phosphorylation of axonal cytoskeleton in multiple sclerosis lesions

Figure 6

IL-16 immunoreactivity is present in occasional infiltrating lymphocytes adjacent to degenerate axonal cytoskeletons, in normal-appearing white matter (NAWM). A) Occasional IL-16-positive CD3+ T cells were observed around small venules in NAWM adjacent to acute lesions in spinal cord (at arrows). B) Note degenerate axonal neurofilaments [NF(M+H)P], which appear rounded, ballooned and irregularly shaped (at arrows). Some IL-16 immunoreactivity was observed in the proximity of axons, either confined to or adjacent to sparse infiltrating mononuclear cells (merged image, arrows). Note that IL-16 does not co-localize with axonal neurofilament. Two color fluorescence × 40.

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Journal of Neuroinflammation

ISSN: 1742-2094