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Figure 3 | Journal of Neuroinflammation

Figure 3

From: Boosting with intranasal dendrimeric Aβ1–15 but not Aβ1–15 peptide leads to an effective immune response following a single injection of Aβ1–40/42 in APP-tg mice

Figure 3

Minimal T cell reactivity to Aβ peptides in dAβ1–15 immunized J20 APP-tg mice. Splenocytes were isolated, pooled into treatment groups and stimulated with Aβ1–40 (A), Aβ1–42 (B) or a combination of Aβ1–40/42 (C) in triplicate. Following 72 hours of incubation, 3[H] thymidine was added and the radioactivity measured after 18 hours. Mice primed by s.c. injection of Aβ1–40/42 and boosted intranasally with Aβ1–40/42 proliferated more than mice in the other treatment groups. J20 APP-tg mice boosted with LT(R192G), Aβ1–15 peptide or dAβ1–15 did not proliferate to any of the peptides (S.I. <2).

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Journal of Neuroinflammation

ISSN: 1742-2094