Figure 4From: Boosting with intranasal dendrimeric Aβ1–15 but not Aβ1–15 peptide leads to an effective immune response following a single injection of Aβ1–40/42 in APP-tg miceNo T cell reactivity in dAβ1–15 immunized wildtype mice. Cells from the spleen and cervical lymph nodes were isolated from B6D2F1 mice that received either a prime injection with Aβ1–40/42 and subsequent boosting intranasally with dAβ1–15 or received intranasal dAβ1–15 alone. The cells were pooled with respect to treatment group and tissue and stimulated in vitro with a mixture of Aβ1–40/42. There was no significant proliferation of cells from either tissue, regardless of the treatment (S.I. <2), thus indicating no population of anti-AβT cells in the draining lymph nodes of the nasal mucosa.Back to article page