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Figure 3 | Journal of Neuroinflammation

Figure 3

From: Interleukin-1 receptor 1 knockout has no effect on amyloid deposition in Tg2576 mice and does not alter efficacy following Aβ immunotherapy

Figure 3

A and B. Aβ levels were significantly reduced following mAb9 immunizations initiated in 6-month-old APP/IL-1 R1-/- mice as well as APP/IL-1 R1+/- mice (n = 3/group). C and D. Aβ levels were not significantly altered following mAb9 immunizations initiated in 12-month-old APP/IL-1 R1-/- mice and APP/IL-1 R1+/- mice (n = 3–5/group). Mice were killed after immunization with 500 μg of mAb9 every other week for 3 months, and both SDS-soluble (SDS) and SDS-insoluble, formic acid extractable (FA) fractions of Aβ40 and Aβ42 were measured by capture ELISA. E and F. Quantitative image analysis of amyloid plaque burden in the neocortex of mAb9 immunizations initiated in 6-month-old APP/IL-1 R1-/- mice (E) and mAb9 immunizations initiated in 12-month-old APP/IL-1 R1-/- mice (F). (*, ** P < 0.05 t-test)

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Journal of Neuroinflammation

ISSN: 1742-2094