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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Fibrillar beta-amyloid peptide Aβ1–40 activates microglial proliferation via stimulating TNF-α release and H2O2 derived from NADPH oxidase: a cell culture study

Figure 1

The effect of Aβ1–40 peptide on microglial proliferation at 24 hours. Microglial cultures were incubated with 1 μM fibrillar (f) or soluble (s) Aβ1–40, the NADPH oxidase inhibitor apocynin (10 μM), and/or with the hydrogen peroxide converters catalase (60 IU/ml) or EUK-8/-134 (20 μM) for 24 hours. After a 24 hour incubation, microglial cells were counted and their numbers expressed as percentage of cell number at time '0'. The dashed line indicates cell number at time '0' i.e. 100%. Data are expressed as mean of 5 experiments ± standard error. Statistical analysis used: Student's t-test, p < 0.05; * – significant difference compared to the control; # – significant difference compared to samples treated with fibrillar Aβ only.

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