Table 1 Kinetic Parameters at Different Inhibitor Concentrations
From: Inhibition of secreted phospholipase A2 by neuron survival and anti-inflammatory peptide CHEC-9
Group I sPLA2 | ||||
|---|---|---|---|---|
[CHEC-9] nM | 0.0 | 0.1 | 1.0 | 10.0 |
Vmax nM/min/ng | 21.67 | 11.54 | 5.56 | 4.04 |
Km μM | 18.80 | 10.77 | 3.40 | 2.26 |
r2 | 0.896 | 0.942 | 0.851 | 0.752 |
Ki = 4.02 ± 1.56 nM | ||||
Human Plasma sPLA2 | ||||
[CHEC-9] nM | 0.0 | 10.0 | 50.0 | |
Vmax μM/min/ml | 2.07 | 1.42 | 0.973 | |
Km | 66.52 | 40.79 | 24.06 | |
r2 | .981 | .957 | .970 | |