Secretory PLA2-IIA: a new inflammatory factor for Alzheimer's disease

Table 2 sPLA₂-IIA-positive astrocytes in hippocampus and inferior temporal gyrus of Alzheimer (AD) and nondemented (ND) subjects.

Brain region	Dentate gyrus		CA3 region		Inferior temporal gyrus
Subjects	AD	ND	AD	ND	AD	ND
Total sPLA ₂ -IIA-positive astrocytes	50.82 ± 9.00^1,***	1.27 ± 0.96	24.11 ± 5.15***	0.00	12.86 ± 2.90***	1.99 ± 0.56
Plaque-associated sPLA ₂ -IIA-positive astrocytes ²	0.66 ± 0.21*	0.00	1.59 ± 0.38**	0.00	8.60 ± 2.74*	0.51 ± 0.35

¹Astrocyte counts are given as percent of all GFAP-positive astrocytes. Values are expressed as mean ± SD.
²Plaque-associated astrocytes were identified by co-staining with thioflavin S
*, **, ***Value is significantly different from corresponding ND value (Student's t test): *p < 0.01; **p < 0.005; ***p < 0.001

ISSN: 1742-2094