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Table 1 Value of 4G8-positive β-amyloid plaques and percentage of reduction when CD40 is disrupted in Tg APPsw and Tg PSAPP mice.

From: CD40 deficiency mitigates Alzheimer's disease pathology in transgenic mouse models

Genotype Studied area

4G8-positive plaque (% of area)

Variation (%) when compared to control

Tg APP> sw

   Frontal cortex

1.75 ± 0.29

n/a*

   Occipital cortex

2.20 ± 0.46

n/a

   Parietal cortex

3.22 ± 0.48

n/a

   Hippocampus

2.67 ± 0.45

n/a

Tg APP sw /CD40 def.

   Frontal cortex

1.06 ± 0.24

40% reduction

   Occipital cortex

1.37 ± 0.33

38% reduction

   Parietal cortex

1.11 ± 0.32

66% reduction

   Hippocampus

0.97 ± 0.30

63% reduction

Tg PSAPP

   Frontal cortex

7.06 ± 0.96

n/a

   Occipital cortex

6.77 ± 1.01

n/a

   Parietal cortex

6.39 ± 1.03

n/a

   Hippocampus

6.99 ± 0.93

n/a

Tg PSAPP/CD40 def.

   Frontal cortex

2.34 ± 0.41

67% reduction

   Occipital cortex

1.80 ± 0.19

73% reduction

   Parietal cortex

2.19 ± 0.39

66% reduction

   Hippocampus

2.47 ± 0.43

65% reduction

  1. *non applicable