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Figure 1 | Journal of Neuroinflammation

Figure 1

From: The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer's disease

Figure 1

Activation of the phagocytic NADPH oxidase complex. Stimulation of the phagocyte induces the parallel activation of oxidase components within the cytoplasm. This activation causes the conversion of Rac into an active GTP-bound form and the phosphorylation of p47phox and p67phox. These subunits then translocate to the membrane where they interact with p22phox and gp91phox (NOX2) to initiate reactive oxygen production.

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