Figure 3From: The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer's diseaseModel of intracellular signaling following Aβ fibril interaction with the microglial cell surface receptor complex. Fibrillar engagement of an ensemble of cell surface receptors initiates a tyrosine kinase-based signaling cascade. Tyrosine phosphorylation of the Vav-GEF results in the activation of downstream Rac1 GTPase.Back to article page