Infarct volume one week after tMCAo. The infarct volume was estimated by means of the 2D nucleator and the Cavalieri principle applied on NeuN stained brain sections one week after surgery. Saline and parecoxib-treated animals are marked with black and red dots (●) respectively. Parecoxib significantly reduced the mean infarct size (p < 0.03). Interestingly, the parecoxib group was divided into two subgroups suggesting a "responder" and "non-responder" phenomenon of the COX-2 inhibitor. All eleven animals in the saline group had an infarction pattern with neocortical involvement. In the parecoxib group only five out of twelve animals had cortical infarction. Mean values are marked as black horizontal lines. * indicate p < 0.03.