Table 1 HLA-B alleles in controls and in Alzheimer's disease
From: Replication of the association of HLA-B7 with Alzheimer's disease: a role for homozygosity?
Allele | Homozygotes/heterozygotes/negatives (n) | Allelic frequency (%) | Unadjusted allelic odds ratio of AD (95% CI, p†) | Hardy-Weinberg equilibrium (p†) | |||
|---|---|---|---|---|---|---|---|
Controls | AD | Controls | AD | Controls | AD | ||
HLA-B7 | 0/42/157 | 7/58/131 | 10.6 | 18.4 | 1.9 (1.3–2.9, 0.002) | 0.1 | 0.85 |
HLA-B8 | 5/49/145 | 6/45/145 | 14.8 | 14.5 | 1.0 (0.7–1.45, 0.9) | 0.7 | 0.3 |
HLA-B18 | 1/16/182 | 1/11/184 | 4.5 | 3.3 | 0.7 (0.35–1.5, 0.5) | 0.3 | 0.08 |
HLA-B27 | 0/11/188 | 0/18/178 | 2.8 | 4.6 | 1.7 (0.8–3.6, 0.2) | 0.7 | 0.5 |
HLA-B35 | 0/22/177 | 1/25/170 | 5.5 | 6.9 | 1.3 (0.7–2.3, 0.5) | 0.4 | 0.9 |
HLA-B39 | 1/9/189 | 0/7/189 | 2.8 | 1.8 | 0.6 (0.25–1.7, 0.5) | 0.025 | 0.8 |
HLA-B44 | 3/56/140 | 7/48/141 | 15.6 | 15.8 | 1.0 (0.7–1.5, 1.0) | 0.3 | 0.3 |
HLA-B51 | 0/20/179 | 1/8/187 | 5.0 | 2.6 | 0.5 (0.2–1.1, 0.09) | 0.5 | 0.01 |
HLA-B57 | 0/19/180 | 1/19/176 | 4.8 | 5.4 | 1.1 (0.6–2.1, 0.75) | 0.5 | 0.5 |
HLA-B60 | 1/31/167 | 0/19/177 | 8.3 | 4.8 | 0.6 (0.3–1.0, 0.06) | 0.7 | 0.5 |
HLA-B62 | 1/31/167 | 0/23/173 | 8.3 | 5.9 | 0.7 (0.4–1.2, 0.2) | 0.7 | 0.4 |
HLA-B65 | 0/13/186 | 1/4/191 | 3.3 | 1.5 | 0.5 (0.2–1.2, 0.2) | 0.6 | 0.0001 |