Figure 7

MPTP-induced deficit in vertical activity is decreased by selective COX-2 inhibitors. An objective measure of the vertical activity, recorded by an automated locomotor activity testing machine, revealed the ability of valdecoxib to maintain rearing activity closer to that of control-saline-treated mice (B) and to their baseline prior to MPTP injection (A). In agreement with the total spontaneous horizontal distance results, vertical activity of valdecoxib-treated mice was statistically less impaired. Data are means ± SEM for eight to twelve mice per group pre-MPTP treatment and six to eight mice per group post-MPTP treatment, and were analyzed by two-way repeated measures ANOVA with Bonferroni post hoc test, *p < 0.05 and ***p < 0.001 compared to the saline+vehicle group; #p < 0.05 and ##p < 0.01 compared to MPTP+vehicle group.