Figure 8

COX-2 deficiency showed a protective effect against motor deficit in MPTP-injected mice. Animals were trained on the rod for two consecutive days before intraperitoneal MPTP (4 × 15 mg/kg, 1.5 hr interval) or saline injection. Mice were assessed for their Rotarod performance on day 2 (A), 4 (B) and 6 (C) after MPTP injection. Motor deficit is observed in the MPTP-treated animals, but deficiency in COX-2 significantly prevents this impairment. Deficiency in COX-2 does not affect baseline motor function in the saline-injected COX-2 HT and KO mice. Data are means ± SEM for six to eight mice per group post-MPTP treatment and analyzed by two-way repeated measures ANOVA with Bonferroni post hoc test, *p < 0.05 compared to the saline+vehicle group and #p < 0.05 compared to MPTP+vehicle group.