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Table 1 Treatment with IFN-γ reduces neuronal survival following incubation with amyloid-β1-42. SH-SY5Y cells or primary neuronal cell cultures were pre-treated with IFN-γ (1 ng/ml) for 24 hours prior to the addition of amyloid-β peptides as shown. Cell survival was determined using the WST-1 test after 24 hours (cell lines) or 4 days (primary neuronal cultures). Each value is the mean percentage cell survival ± SD from triplicate experiments repeated 3 times (9 observations). ** = Neuronal survival significantly less than untreated neurons incubated with amyloid-β1-42 (p < 0.05).

From: Interferon-γ increases neuronal death in response to amyloid-β1-42

  % Neuronal Survival
Cell Type Amyloid-β 1-42 Amyloid-β 42-1
  Control IFN-γ Control IFN-γ
SH-SY5Y cells 62 ± 4 33 ± 9** 101 ± 4 98 ± 7
Cortical neurons 68 ± 7 36 ± 7** 98 ± 3 96 ± 5
Cerebellar neurons 79 ± 4 58 ± 11** 101 ± 8 102 ± 8