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Table 3 Pre-treatment with IFN-γ increases prostaglandin E2 production in response to amyloid-β or HuPrP82-146. SH-SY5Y neuroblastoma cells were pre-treated for 24 hours with 1 ng/ml cytokines as shown prior to the addition of amyloid-β or PrP peptides. Cells were lysed 24 hours later and total prostaglandin E2 levels were measured. Each value given represents the mean ± SD from triplicate experiments repeated twice (6 observations). ** = Prostglandin E2 levels significantly higher than untreated neurons incubated with amyloid-β1-42 (p < 0.05).

From: Interferon-γ increases neuronal death in response to amyloid-β1-42

  Prostaglandin E2 (pg/ml)
  Amyloid-β 1-42 Amyloid-β 42-1 HuPrP82-146 HuPrP82-146sc
Control medium 241 ± 62 < 50 187 ± 40 < 50
IFN-γ 443 ± 112** 66 ± 38 303 ± 55** < 50
IL-1β 228 ± 54 < 50 202 ± 46 < 50
IL-6 218 ± 66 < 50 210 ± 48 55 ± 35
TNFα 255 ± 82 < 50 214 ± 33 < 50