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Figure 4 | Journal of Neuroinflammation

Figure 4

From: Hypoxia-inducible factor-1 (HIF-1) is involved in the regulation of hypoxia-stimulated expression of monocyte chemoattractant protein-1 (MCP-1/CCL2) and MCP-5 (Ccl12) in astrocytes

Figure 4

Effects of CoCl2 treatment on MCP-5 expression in mouse HIF-1α+/- and HIF-1α+/+ astrocytes. The cells were incubated in the presence or absence of 125 μM CoCl2 for 6 hr. MCP-5 expression at the mRNA and protein levels was determined by RT-PCR (A) and ELISA (B), respectively. Each bar represents the mean ± SD of relative density/volumes of the bands on film negatives from least three experiments or three ELISA assays. Asterisks and number signs indicate significant difference compared to relevant controls (p < 0.01; one-way ANOVA, followed by multiple comparisons among means).

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