Posttraumatic injection of mAb 1379 attenuates C5a levels in serum of head-injured mice. Serum samples from mice treated with placebo or mAb1379 were analyzed by a specific murine C5a ELISA, as described in the methods section. C5a levels were significantly decreased in mAb1379-treated mice compared to placebo controls at 4 and 24 hours (P < 0.05, unpaired Student's t-test), but not at 7 days after trauma (n.s., not significant). Data are shown as mean levels ± SD of n = 3 animals per group and time-point. *P < 0.05 head-injured placebo-injected mice vs. normal controls (unpaired Student's t-test). TBI, traumatic brain injury.