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Figure 4 | Journal of Neuroinflammation

Figure 4

From: Inhibition of the alternative complement activation pathway in traumatic brain injury by a monoclonal anti-factor B antibody: a randomized placebo-controlled study in mice

Figure 4

Neurological outcome after head injury is not altered by injection of mAb 1379. The extent of neurological impairment was assessed using a standardized 10-parameter "Neurological Severity Score" (NSS) in normal, sham-operated, and head-injured mice from 1 hour to 7 days after trauma (total: n = 89 mice). Neurological assessment was performed by two investigators in a blinded fashion. A maximal score of 10 points corresponds to a severe neurological impairment, while a score of 0 points reflects normal behavior [41,43]. The graph shows median levels of the groups at different time-points. No statistically significant differences where found at any time-point between head-injured mice treated with either mAb 1379 or placebo (P > 0.05, repeated measures ANOVA). TBI, traumatic brain injury.

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