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Figure 2 | Journal of Neuroinflammation

Figure 2

From: Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE

Figure 2

Distribution of CCR1, CCR2, CCR5 mRNA expressing cells at different time points in the spinal cord of MOG-EAE rats. In situ hybridization with 35S-labelled antisense cRNA probes encoding rat CCR1, CCR2 and CCR5 to coronal sections from the lumbar segment of spinal cord of rats with MOG-EAE. Cells expressing CCR1, CCR2 and CCR5 mRNA are visualized by dark field illumination of the photo emulsion-dipped slides. Intensive signals for CCR1 and CCR5 mRNA, and moderate signals for CCR2 mRNA, were detected on days 13 (B, E, H) and 24 (C, F, I) post immunization. No signal for CCR1, CCR2 or CCR5 mRNA was detected in healthy control animals (A, D, G). No signal was detected in control sections hybridized with sense probe (not shown).

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Journal of Neuroinflammation

ISSN: 1742-2094