Effect of gabapentin on wind-up. The administration of gabapentin dose-dependently reduced the wind-up phenomenon in neuropathic rats with maximal reduction of 55 ± 20% of control (P < 0.01). Gabapentin was not efficacious in the reduction of wind-up in normal and arthritic animals. The figure shows the effect of gabapentin on wind-up as percentage of control (all groups) and as actual number of C-fiber mediated responses (inset, data for neuropathic rats; only some doses are shown for clarity. *P < 0.05, *P < 0.01, comparison vs. control response with the one-way ANOVA, with the post-hoc Tukey test).