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Figure 3 | Journal of Neuroinflammation

Figure 3

From: Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated α-synuclein

Figure 3

Lack of EP2 attenuated formation of NP40-insoluble α-synuclein aggregates in both SN and striatum. SN and striatum were dissected at 5 weeks after the last treatment and fractionated into NP40-soluble and NP40-insoluble/SDS-soluble fractions, followed by assessment by Western blot. Data is expressed as NP-40 insoluble (SDS-soluble) α-synuclein aggregates as a fraction of total (NP40- and SDS-) soluble α-synuclein. *: p < 0.05 comparing WT-MPTP vs. WT-control (con) and EP2-/--MPTP vs. WT-MPTP, respectively, in the SN. **: p < 0.01 comparing EP2-/--MPTP vs. WT-MPTP in the striatum (n = 8).

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Journal of Neuroinflammation

ISSN: 1742-2094