Figure 3

Comparison of resting and activated microglia in control and cholesterol-fed rabbits. A–D, dentate gyrus showing granule cell layer (near top) and hilus. Normal distribution of resting microglia in control rabbit (A) stands in contrast to activated microglia in hypercholesterolemic rabbits (B–D). Panel B shows diffuse distribution of activated microglia; panel C shows focal accumulations of activated microglia; panel D shows a combination of diffuse and focal patterns. E–G, high power views of various microglial morphologies, including resting cells (E), rod cells in stratum radiatum (F), and activated cells (G). Cresyl violet counterstain. Scale bars: 200 μm (A–D); 50 μm (E–G)