Skip to main content
Figure 1 | Journal of Neuroinflammation

Figure 1

From: A novel p38α MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model

Figure 1

Synthetic scheme for synthesis of MW01-2-069A-SRM. Reactions, conditions and yields: a) POCl3, reflux, 2 hrs, 99%; b) NaOH, H2O, reflux, 2 hrs, 67%; c) 1-(2-pyrimidyl)piperazine, 1-butanol, 130°C, 26 hrs, 98%; d) POCl3, reflux, 3 hrs, 99%; e) 4-pyridylboronic acid, Pd(PPh3)4, K2CO3, DME, 110°C, 15 hrs, 74%.

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094