Figure 6

Compound 069A attenuates synaptic protein loss and behavioral deficits in AD mouse model. Treatments, behavioral testing, and preparation of hippocampal extracts were done as described in Figure 5. Treatment with 069A significantly attenuated Aβ-induced loss of synaptophysin (A) and the behavioral deficit in the Y-maze (B). Data are means ± SEM of n = 5–12 mice per group. Significantly different from Aβ-injured: *p < 0.05, **p < 0.01.