Figure 1

MT-MMP gene expression in active and AT-EAE in B6 mice. Gene expression levels of MT-MMPs in spinal cord from unmanipulated B6 mice and mice with severe (grade 4) EAE were measured by real-time PCR. EAE was induced either by immunization with MOG_35–55 in CFA (active) or adoptive transfer of MOG_35–55 specific T cells (AT-EAE). Values on the Y-axis are relative to expression of 18S rRNA, and normalized to the expression level of the unmanipulated group. The values are arbitrary and cannot be compared between panels. n = 4 or 5. Unm.: unmanipulated; Act.: active; *: p ≤ 0.05.