A: Immunoblot analysis of protein levels of COX-1, COX-2, mPGES-1, and actin in LPS-activated microglia treated with different concentrations of resveratrol (1–50 μM). Microglial protein extracts were prepared after 24 h of incubation with LPS, and subjected to SDS-PAGE followed by immunoblot analysis using specific antibodies for each protein. B: Quantitative densitometric analysis of mPGES-1 and COX-2 protein expression normalized to actin loading control. Resveratrol potently reduced mPGES-1 protein expression induced by LPS. *p < 0.05 and **p < 0.01 with respect to untreated LPS control. Bars represent mean ± S.E.M. of 4 independent experiments.