Figure 2
From: Amyloid precursor protein modulates β-catenin degradation
APP facilitates β-catenin degradation by increasing β-catenin phosphorylation at S33/37/T41 residues. A. Primary neurons infected with APP contained less steady-state β-catenin and higher levels of phosphorylated S33/37/T41 than did neurons infected with control LacZ (2 IU virus per cell). Levels of phosphorylated S45 did not appear to change. B. Quantitative analyses of western blots from 3 independent experiments. APP significantly increased β-catenin phosphorylation at S33/37/T41 residues (p = 0.02, t-Test), but not at S45 residue (p = 0.19, t-Test).