Figure 3
From: Amyloid precursor protein modulates β-catenin degradation
Suppression of endogenous APP results in increased total β-catenin and decreased S33/37/T41-phosphorylated β-catenin. Primary neurons were infected with APPshRNA (APP1996) or missense shRNA viruses (0.5 IU/cell) for 14 h before harvest and protein analyses. The mean optical densities of 3 independent experiments for each protein analyzed are presented in the Y-axis in the bar graphs. The statistical significance of difference is also presented in each bar graph (p values from t-Test) for each protein analyzed (labelled on the Y-axis). Representative blots are shown on the right. Loading controls were γ-tubulin reprobed from the same blots.