Figure 3

CD45 and MHC II immunoreactivity in op/op and wildtype mice. CD45 immunoreactivity is reduced in the hippocampus of op/op mice (A) as compared to age matched wildtype mice (B). Only larger round cells located near blood vessels were labeled in the op/op mice, whilst in wildtype mice ramified microglia can be found. In both op/op (C) and wildtype (D) mice MHC II immunoreactive cells were found solely in the choroid plexus, while the overlying hippocampus was devoid of labeled cells. scale bar – 100 μm.