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Figure 6 | Journal of Neuroinflammation

Figure 6

From: Osteopetrotic (op/op) mice have reduced microglia, no Aβ deposition, and no changes in dopaminergic neurons

Figure 6

Cryosections from 30 day old op/op, wildtype and 12 month old APP-tg mice were examined using commercially available polyclonal antibodies for Aβ40 and Aβ42. There was no Aβ40 immunoreactivity in op/op (A), wildtype (B) mice, whilst the APP-tg (C) mouse section showed some dense plaques. The Aβ42 specific antibody demonstrated a similar finding with op/op (D) and wildtype (E) mice having no plaques, whilst APP-tg (F) mice showed clear labeling of plaques. scale bar – 500 μm.

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Journal of Neuroinflammation

ISSN: 1742-2094