Cholesterol synthesis inhibitors protect against platelet-activating factor-induced neuronal damage

Table 1 Squalene reverses the effects of squalestatin on the amounts of cholesterol in neurons

Treatment	Substrate
	None	50 μM Squalene	100 μM Mevalonate
	*Neuronal cholesterol content (ng/mg protein)*
None	496 ± 42	472 ± 53	482 ± 53
100 nM Squalestatin	297 ± 32	475 ± 32	284 ± 29
500 Nm Simvastatin	331 ± 50	501 ± 46	485 ± 68

The amounts of cholesterol in primary cortical neurons treated for 24 hours with different combinations of either squalestatin or simvastatin together with either squalene or mevalonate as shown. Values shown are the mean average ± SD from 6 observations.